November 2011

Kognitive modeller for depression og neurobiologi

Kognitiv psykoterapi er i dag én af de evidensbaserede behandlingsmodaliteter, der kan tilbydes patienter med især lette til moderate depressioner. Behandlingen er baseret på kognitive teorier, der er udviklet ud fra Aaron Becks klassiske model. Relationen til grundlæggende neurobiologi er dog utilstrækkeligt afklaret. Denne måneds artikel er dermed interessant fordi den kommer med bud på mulige sammenhæng mellem de centrale kognitive begreber og deres hjernemæssige forankring. Artiklen er vel illustreret med 129 referencer, heraf flere i annoteret form.

Nat Rev Neurosci. 2011 Jul 6;12(8):467-77. doi: 10.1038/nrn3027.
Neural mechanisms of the cognitive model of depression.
Disner SG, Beevers CG, Haigh EA, Beck AT.
The University of Texas at Austin, Department of Psychology, 1 University Station, A8000, Austin, Texas 78712, USA.
Link: http://www.ncbi.nlm.nih.gov/pubmed/21731066

Abstract
In the 40 years since Aaron Beck first proposed his cognitive model of depression, the elements of this model–biased attention, biased processing, biased thoughts and rumination, biased memory, and dysfunctional attitudes and schemas–have been consistently linked with the onset and maintenance of depression. Although numerous studies have examined the neural mechanisms that underlie the cognitive aspects of depression, their findings have not been integrated with Beck’s cognitive model. In this Review, we identify the functional and structural neurobiological architecture of Beck’s cognitive model of depression. Although the mechanisms underlying each element of the model differ, in general the negative cognitive biases in depression are facilitated by increased influence from subcortical emotion processing regions combined with attenuated top-down cognitive control.

Raben Rosenberg
DPS’ Forskningsudvalg